ens@t-ht

ens@t-ht is an EU-funded Horizon 2020 research and innovation project that will investigate specific types of hypertension and whether it is possible to define specific profiles based on systems biology "-omics" approaches and subsequently use these to define more personalised approaches to disease management.

The project will develop and evaluate an omics-based stratified health promotion programme for patients with endocrine forms of hypertension.

We will define specific omics profiles for patients with primary aldosteronism, pheochromocytoma/functional paraganglioma and Cushing’s syndrome by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling.

Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications.

Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalized treatment.

The project will develop and evaluate an omics-based stratified health promotion programme for patients with endocrine forms of hypertension.

The project comprises of a number of work packages that will focus on specific aspects and tasks. You can get an overview and the context of the project here. Below you can find out more about each work package and how they relate to each other.